9 Common and Serious Side Effects of Motrin

Alan Lucks | MD

Medically reviewed by Alan Lucks | MD, Alan Lucks MDPC Private Practice - New York on December 3rd, 2025.

Key Takeaways

  • Motrin, a popular pain reliever, can cause side effects ranging from mild to serious.

  • Common side effects include stomach upset and dizziness, while serious ones may require immediate medical attention.

  • Understanding these side effects helps you use Motrin safely and effectively.

  • For personalized advice and quick telehealth visits, services like Doctronic.ai offer expert support anytime.

Understanding Motrin Side Effects

Motrin (Ibuprofen) is a popular medication for reducing pain, fever, and inflammation, but it can cause side effects ranging from mild to serious. This guide highlights key symptoms to watch for, how to manage them, and when to seek help. Taking Motrin with food can protect your stomach and lower the risk of irritation or ulcers, especially with long-term use. Because Motrin may not be safe for people with kidney, heart, or stomach conditions, consulting a healthcare provider is important. For quick support and guidance, Doctronic.ai offers accessible telehealth visits to help you stay informed and safe during treatment.

1. Stomach Pain and Upset

One of the most common side effects of Motrin is stomach discomfort. This happens because ibuprofen can irritate the stomach lining, sometimes causing pain, nausea, or indigestion. For some people, this may feel like mild discomfort, but for others, it can be more intense.

Taking Motrin with food or milk often helps reduce stomach upset. If pain lasts or worsens, it’s important to stop the medication and check in with a healthcare provider.

2. Heartburn and Acid Reflux

Motrin can increase acid production in the stomach, leading to heartburn or acid reflux. This burning sensation in the chest or throat can be uncomfortable and may affect sleep or daily activities.

To ease heartburn, avoid lying down right after taking Motrin and consider antacids if recommended by your doctor. Persistent or severe symptoms should be evaluated by a healthcare professional.

3. Dizziness and Lightheadedness

Feeling dizzy or lightheaded is another reported side effect. This might happen because Motrin can affect blood pressure or cause dehydration in some cases.

Make sure to stay hydrated and avoid sudden movements when standing up. If dizziness is severe or leads to fainting, seek medical advice promptly.

4. Headache

Although Motrin is often used to treat headaches, paradoxically, it can sometimes cause them. This may be due to rebound headaches if the medication is overused or taken too frequently.

To prevent this, follow the dosing instructions carefully and avoid taking Motrin for more than a few days without consulting a doctor.

5. Rash or Skin Reactions

Some people may develop a rash or other skin irritation after taking Motrin. This can range from mild redness to more serious reactions like hives or swelling.

If you notice any unusual skin changes, stop the medication and contact a healthcare provider immediately, especially if the rash spreads or is accompanied by difficulty breathing.

6. Ringing in the Ears (Tinnitus)

Tinnitus, or ringing in the ears, can occur with higher doses or prolonged use of Motrin.
This side effect is usually temporary but can be bothersome.

If you experience persistent ringing or hearing changes, talk to your doctor about adjusting your medication.

7. Kidney Problems

Motrin can affect kidney function, especially in people who already have kidney issues or take it for a long time. Signs of kidney problems include swelling in the legs, decreased urine output, or unusual fatigue.

Regular monitoring and avoiding high doses can help protect your kidneys. If you notice any symptoms, get medical help right away.

8. Increased Blood Pressure

Ibuprofen may cause a rise in blood pressure in some individuals. This is important for people with hypertension or heart conditions to consider.

Monitoring your blood pressure while using Motrin is a good idea, and discuss any concerns with your healthcare provider.

9. Gastrointestinal Bleeding

One of the more serious side effects is gastrointestinal bleeding. This can happen if Motrin irritates the stomach lining enough to cause ulcers or bleeding. Symptoms include black or bloody stools, vomiting blood, or severe stomach pain.

If you experience these symptoms, seek emergency medical care immediately.

Orange tablets scattered on a two-tone white and yellow surface.How to Manage and Reduce Side Effects of Motrin

Take Motrin with Food

Eating before or with your dose can cushion your stomach and reduce irritation. This simple step often prevents many common stomach-related side effects.

Use the Lowest Effective Dose

Taking the smallest dose that relieves your symptoms lowers the risk of side effects. Avoid exceeding the recommended amount or duration without medical advice.

Stay Hydrated

Drinking plenty of water helps prevent dizziness and supports kidney health while using Motrin.

Monitor Your Symptoms

Keep track of any new or worsening symptoms. If you notice serious side effects like rash, bleeding, or severe pain, seek medical attention right away.

Motrin Allergic Reactions and Warnings

Though rare, some people have allergic reactions to Motrin. Signs include swelling of the face, lips, tongue, or throat, difficulty breathing, or severe rash. These reactions require immediate emergency care.

People with asthma, bleeding disorders, or certain heart and kidney conditions should use Motrin cautiously and under medical supervision.

When to Contact Your Doctor About Motrin Side Effects

Contact your healthcare provider if you experience:

  • Severe stomach pain or vomiting blood

  • Black or bloody stools

  • Swelling, especially in the face or throat

  • Persistent dizziness or fainting

  • Signs of kidney issues, such as reduced urination or swelling

For quick advice or to discuss your symptoms, consider using Doctronic.ai. Their AI-powered platform offers fast, personalized care and telehealth visits with licensed doctors 24/7.

Learn More About Motrin Side Effects With Doctronic

Doctronic combines the latest medical research with personalized AI to help you understand Motrin side effects based on your health history. Whether you want answers about common side effects or need a second opinion, Doctronic’s AI doctor is available anytime online.

With over 10 million users, Doctronic offers free AI doctor visits and affordable telehealth appointments under $40. This makes it easy to get trusted medical advice without leaving home.

The Bottom Line About Motrin Side Effects

Motrin is a helpful medicine for many types of pain and fever. Knowing the common and serious side effects lets you use it wisely and avoid problems. Always follow dosing instructions and listen to your body.

If side effects worry you or symptoms become severe, don’t hesitate to reach out to a healthcare provider. Telehealth services like Doctronic.ai make it easy to get expert advice quickly from home.

Frequently Asked Questions

It’s best to talk with your doctor first. Motrin can irritate the stomach, so if you have ulcers or gastritis, your doctor may recommend alternatives.

Long-term use should be under medical supervision due to risks like kidney damage and high blood pressure. Use the lowest effective dose for the shortest time possible.

Take it as soon as you remember, unless it’s close to your next dose. Do not double up to catch up.

Yes, especially blood thinners, blood pressure medicines, and other NSAIDs. Always inform your healthcare provider about all medications you take.

Doctronic.ai offers fast, affordable telehealth visits and AI-powered answers tailored to your needs. It’s a convenient way to get help anytime.

References

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