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Diclegis is a delayed-release tablet combining doxylamine (an antihistamine) and pyridoxine (vitamin B6). Doxylamine reduces nausea signals in the brain, while pyridoxine supports normal nerve function and has been shown to lessen pregnancy-related nausea. Together they provide longer-lasting relief, especially overnight and into the morning.

Diclegis is the only medication with FDA approval specifically for nausea and vomiting of pregnancy. Clinical studies support its safety for the developing baby when used as directed. Your physician will review your full medical history before prescribing to confirm it is appropriate for your individual situation.

The standard starting dose is two tablets taken at bedtime. If symptoms are not adequately controlled, your physician may adjust the regimen to include an additional tablet in the morning or mid-afternoon. Tablets should be swallowed whole and not crushed, chewed, or split, as this affects the delayed-release mechanism.

The most frequently reported side effect is drowsiness, which is why the medication is typically started at bedtime. Other possible effects include dry mouth, dry eyes, and dizziness. You should avoid driving or operating heavy machinery until you know how Diclegis affects you.

Diclegis is indicated for nausea and vomiting of pregnancy, but hyperemesis gravidarum (severe, persistent vomiting causing dehydration and weight loss) often requires additional medical management, including IV fluids and other antiemetics. Your physician will evaluate the severity of your symptoms to determine the most appropriate treatment plan.

Diclegis can interact with other central nervous system depressants, including alcohol, sedatives, and certain antihistamines, increasing drowsiness and sedation. Monoamine oxidase inhibitors (MAOIs) are contraindicated with doxylamine. Always share a complete list of your medications and supplements with your physician before starting Diclegis.

Doctronic uses an AI-guided evaluation to gather detailed information about your symptoms and medical history. A licensed physician then reviews your case, makes an independent clinical determination, and, if appropriate, creates a personalized treatment plan that may include a prescription. Every step is doctor-reviewed and medically supervised.

Yes. Doctronic works exclusively with licensed physicians who are board-certified and credentialed in their states. All consultations are HIPAA-compliant, and clinical decisions are regularly audited to ensure they meet high standards of care. Doctronic is available to adults 18 and older in any U.S. state.