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Moduretic is a combination prescription tablet containing amiloride and hydrochlorothiazide. It is used to treat fluid retention (edema) associated with heart failure, liver cirrhosis, and hypertension. The two ingredients work together: hydrochlorothiazide increases urine output, while amiloride helps prevent the potassium loss that hydrochlorothiazide can cause.

Hydrochlorothiazide acts on the distal convoluted tubule of the kidney to reduce sodium and water reabsorption, which can also cause potassium loss. Amiloride blocks sodium channels in the collecting duct, reducing potassium excretion at the same time. Together, they provide effective diuresis while minimizing hypokalemia risk.

Common side effects include increased urination, dizziness, headache, nausea, and muscle cramps. More serious concerns include elevated potassium levels (hyperkalemia), low sodium (hyponatremia), and changes in blood glucose or uric acid. Contact your provider promptly if you notice muscle weakness, irregular heartbeat, or significant swelling.

Moduretic should not be used by people with high potassium levels (hyperkalemia), significant kidney impairment, anuria, or a known allergy to sulfonamide-derived medications. It should also be avoided in patients already taking other potassium-sparing diuretics or potassium supplements without close medical supervision, as the combination can cause dangerous potassium elevations.

Your provider will typically monitor your kidney function (BUN and creatinine), serum electrolytes (especially potassium and sodium), and blood pressure periodically. Patients with diabetes may also need blood glucose monitoring, since hydrochlorothiazide can affect insulin sensitivity. Regular follow-up helps ensure the dose remains appropriate and safe.

Yes. Moduretic can interact with ACE inhibitors, ARBs, potassium supplements, NSAIDs, lithium, and certain diabetes medications. NSAIDs may reduce its diuretic effect, while ACE inhibitors and ARBs can increase hyperkalemia risk. Always share your full medication list with your provider before starting Moduretic.

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Yes. Doctronic connects you with fully licensed physicians who are board-certified and practice in compliance with state medical regulations. All consultations are HIPAA-compliant, and every treatment decision is doctor-reviewed. Doctronic is available to adults 18 and older in any U.S. state.