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Clindesse is a clindamycin 2% vaginal cream used to treat bacterial vaginosis. It works by binding to bacterial ribosomes and blocking protein synthesis, which stops the growth of the anaerobic bacteria that cause the infection. It is administered as a single dose inserted into the vagina.

Clindesse is formulated as a single-dose, bioadhesive cream that delivers clindamycin over a longer contact time in the vagina, allowing one-time use instead of the 7-day regimen required by standard clindamycin vaginal cream products like Cleocin.

The most commonly reported side effects include vaginal yeast overgrowth (vulvovaginal candidiasis), vaginal discharge, itching, or burning. Because clindamycin can disrupt normal vaginal flora, some women develop a yeast infection after treatment. Contact your provider if symptoms worsen or do not improve.

Yes. The oil-based formulation in Clindesse can weaken latex and rubber products such as condoms and diaphragms for up to 5 days after use. You should use an alternative form of contraception during this period to maintain protection.

Clindesse is a single-dose medication, so the full course is one application. However, it is important to avoid sexual intercourse immediately after insertion and to follow your provider's instructions to allow the medication to work effectively.

Yes. Bacterial vaginosis has a notable recurrence rate even after successful treatment. If your symptoms return after completing Clindesse therapy, contact your provider. They may recommend a different antibiotic regimen, extended therapy, or evaluation for other contributing factors.

Clindesse should not be used by people with a known hypersensitivity to clindamycin, lincomycin, or any component of the formulation. It is also generally not recommended for individuals with a history of antibiotic-associated colitis. Your Doctronic provider will screen for these contraindications during your evaluation.

Doctronic uses an AI-powered evaluation to gather your symptoms and health history, which is then reviewed by a licensed physician who creates a personalized treatment plan. All providers are U.S.-licensed, consultations are doctor-reviewed and audited, and the platform is fully HIPAA-compliant.