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Januvia (sitagliptin) is a DPP-4 inhibitor prescription medication for type 2 diabetes. It works by blocking the enzyme DPP-4, which breaks down incretin hormones. Higher incretin levels cause the pancreas to release more insulin after meals and signal the liver to produce less glucagon, both of which help lower blood sugar levels.

Yes. Januvia is commonly prescribed alongside metformin, SGLT-2 inhibitors, or insulin. Janumet is a combination pill that pairs sitagliptin with metformin in one tablet. Always tell your physician about all medications you are taking so they can check for interactions.

The most commonly reported side effects include upper respiratory tract infections, stuffy or runny nose, sore throat, and headache. More serious but rare risks include pancreatitis, severe joint pain, and allergic reactions. Contact your doctor right away if you experience severe abdominal pain or signs of an allergic reaction.

On its own, Januvia has a low risk of causing hypoglycemia (low blood sugar) because it works in a glucose-dependent manner. However, if you take Januvia together with insulin or a sulfonylurea, the risk of low blood sugar increases. Monitor your glucose levels as directed by your physician.

Januvia is typically taken once daily, with or without food. The standard dose for most adults is 100 mg per day. Your physician may prescribe a lower dose if you have reduced kidney function. Take it at the same time each day and follow your provider's instructions closely.

Your physician will typically recommend periodic HbA1c tests every 3 to 6 months to assess long-term blood sugar control. Kidney function tests (creatinine and eGFR) are also important because Januvia dosing is adjusted based on kidney health. Fasting glucose checks may be recommended as well.

Doctronic uses an AI-powered evaluation to gather information about your symptoms, medical history, and current medications. A licensed physician then reviews your case, and if appropriate, creates a personalized treatment plan that may include a prescription. The entire process is designed to be fast, thorough, and convenient.

Yes. Doctronic connects you with real, licensed physicians who review and approve every treatment plan. All consultations are doctor-reviewed and audited for clinical quality, and the platform is fully HIPAA-compliant to protect your personal health information. Doctronic is available to adults 18 and older in any U.S. state.