Medically reviewed by Alan Lucks | MD, Alan Lucks MDPC Private Practice - New York on January 2nd, 2026.
Bupropion SR is a well-known medication used primarily to treat depression and help people quit smoking. Unlike immediate-release forms, the sustained-release (SR) version releases the drug gradually, allowing for fewer doses per day and a steadier effect. Understanding the correct dosage is crucial to maximizing benefits and minimizing side effects like insomnia or seizures. This guide breaks down typical dosages, how to take them, and what to do if you miss a dose.
Form |
Strength |
Typical Adult Dose |
Typical Children’s Dose |
Frequency |
Route |
Maximum Daily Dose |
|---|---|---|---|---|---|---|
Tablet (Sustained Release) |
100 mg |
150 mg once daily initially, increasing to 150 mg twice daily |
Not commonly prescribed |
Twice daily |
Oral |
400 mg/day |
Tablet (Sustained Release) |
150 mg |
150 mg twice daily |
Not commonly prescribed |
Twice daily |
Oral |
400 mg/day |
For adults with MDD, the usual starting dose is 150 mg once daily in the morning. After 3 to 7 days, the dose is often increased to 150 mg twice daily. The maximum recommended dose is 400 mg per day, split into two doses. This helps maintain steady blood levels and reduces the risk of side effects.
When treating SAD, the dosing is similar to MDD. Patients typically start at 150 mg once daily and increase to 150 mg twice daily. The medication is usually started before the onset of symptoms in the fall and continued through the winter months.
Bupropion SR is also prescribed to support quitting smoking. The typical regimen starts at 150 mg once daily for 3 days, then increases to 150 mg twice daily. Treatment usually begins one to two weeks before the quit date and continues for 7 to 12 weeks or longer, depending on patient response.
The most common adult dose begins at 150 mg once daily, usually taken in the morning to avoid insomnia. After a week, the dose is increased to 150 mg twice daily, spaced at least 8 hours between doses. The maximum dose should not exceed 400 mg per day to reduce the risk of seizures.
Bupropion SR is not commonly prescribed for children and adolescents due to limited safety data. When it is used, dosing must be carefully managed by a healthcare provider. If you are considering bupropion for a younger person, it is essential to consult a specialist or use telehealth services like Doctronic.ai to get expert guidance tailored to the individual.
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Do not double the dose to catch up. Doubling up can increase the risk of side effects, especially seizures. If you are unsure, contact your healthcare provider or use telehealth services for advice.
Patients with moderate to severe liver impairment may require dose adjustments. The liver metabolizes the drug so that impaired function can increase blood levels and side effects. Your healthcare provider will determine the safest dose.
Although bupropion is primarily metabolized in the liver, severe kidney impairment may also necessitate dose adjustments. Close monitoring is recommended.
Taking more than the prescribed dose of bupropion SR can lead to serious side effects, including seizures, hallucinations, and rapid heartbeat. If an overdose is suspected, seek emergency medical attention immediately. Always follow dosing instructions carefully and consult your healthcare provider if you experience unusual symptoms.
Take doses at the exact times each day to maintain steady blood levels.
Swallow tablets whole; do not crush or chew sustained-release tablets.
Avoid taking bupropion late in the day to prevent insomnia.
Inform your doctor about all medications and supplements you are taking to avoid interactions.
Report any side effects such as mood changes, agitation, or seizures immediately.
When it comes to medication like bupropion SR, personalized advice is invaluable. Doctronic offers free AI doctor visits that provide quick, evidence-based answers tailored to your health history. If you need a doctor’s consultation, Doctronic also provides affordable telehealth video visits with licensed physicians across all 50 states, available 24/7.
Visit Doctronic.ai for personalized dosage recommendations and expert medical guidance whenever you need it. This is especially useful if you have questions about adjusting doses or managing side effects.
Combining bupropion with other antidepressants can increase the risk of side effects and interactions. Always consult your doctor before combining medications.
Common side effects include dry mouth, insomnia, nausea, dizziness, constipation, tremors, and headache. If side effects are severe or persistent, contact your healthcare provider or use Doctronic’s telehealth services for advice.
Do not stop taking bupropion without consulting your doctor. Sudden discontinuation can cause withdrawal symptoms or relapse of your condition.
It may take several weeks (usually 4 to 6) to notice full benefits. Continue taking the medication as prescribed and discuss any concerns with your provider.
Alcohol can increase the risk of seizures and other side effects. It’s best to avoid or limit alcohol while on bupropion.
Doctronic.ai offers AI-powered, doctor-led telehealth consultations that provide personalized dosage and treatment advice tailored to your needs.
Starting a new medication can feel overwhelming. Bupropion SR’s dosing schedule is designed to be manageable while reducing side effects. Remember, the goal is to find the dose that works best for you with the fewest risks. Regular communication with your healthcare provider or a trusted telehealth platform, such as Doctronic.ai, ensures your treatment stays on track.
Understanding Bupropion SR Uses and DosagesBupropion SR is a well-known medication used primarily to treat depression and help people quit smoking. Unlike immediate-release [...]
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