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Fetzima (levomilnacipran) is an FDA-approved prescription medication indicated for the treatment of major depressive disorder (MDD) in adults. It is an SNRI that works by increasing serotonin and norepinephrine activity in the brain.

Compared to other SNRIs such as venlafaxine or duloxetine, levomilnacipran exhibits a relatively greater preference for inhibiting norepinephrine reuptake over serotonin reuptake. This pharmacological profile may influence its side effect pattern and effectiveness in individual patients.

Fetzima is typically started at 20 mg once daily for two days, then increased to 40 mg once daily. The dose may be titrated in increments of 40 mg at intervals of two or more days, up to a maximum of 120 mg once daily, based on tolerability and clinical response.

Common side effects include nausea, constipation, increased heart rate, elevated blood pressure, excessive sweating, and difficulty urinating. Most side effects are dose-dependent and may improve as your body adjusts to the medication. Contact your provider if side effects are severe or persistent.

Fetzima can interact with MAO inhibitors, other serotonergic drugs, NSAIDs, aspirin, and blood thinners, potentially increasing the risk of serotonin syndrome or bleeding. Always provide your physician with a full list of medications, supplements, and herbal products you are taking.

Abruptly stopping Fetzima is not recommended. Discontinuation syndrome can occur, with symptoms such as dizziness, irritability, nausea, and sensory disturbances. Your physician will guide you through a gradual taper if you and your provider decide to stop the medication.

Doctronic uses an AI-driven evaluation to gather your health history and symptoms, which a licensed physician then reviews to develop a personalized treatment plan. If a refill or new prescription is appropriate, the physician issues it directly through the platform.

Yes. Doctronic connects patients with licensed physicians whose prescribing decisions are doctor-reviewed and regularly audited for quality. The platform is HIPAA-compliant, and care is available to adults 18 and older in any U.S. state.