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Progesterone is prescribed for secondary amenorrhea (absent periods), luteal phase deficiency, hormone replacement therapy in menopausal women who have a uterus, and luteal phase support in assisted reproductive technology (ART) cycles such as IVF.

Prometrium is an oral micronized progesterone capsule taken by mouth. Crinone is a vaginal gel, and Endometrin is a vaginal insert. All three deliver progesterone but differ in their route of administration, dosing schedules, and the clinical settings in which they are most commonly used. Your provider will recommend the best option for your situation.

For secondary amenorrhea, withdrawal bleeding usually occurs within 2 to 14 days after completing a course of progesterone. For luteal phase support in ART, progesterone is continued until adequate placental progesterone production is established, typically around 8 to 10 weeks of pregnancy.

Common side effects of oral Prometrium include drowsiness, dizziness, headache, bloating, and breast tenderness. Vaginal formulations (Crinone, Endometrin) may cause local irritation or discharge. Drowsiness with oral progesterone is often why it is dosed at bedtime.

Yes. Progesterone is frequently prescribed during early pregnancy to support the uterine lining and maintain the pregnancy, particularly in women undergoing ART or those with a history of recurrent pregnancy loss. Your physician will determine whether this is appropriate for your specific situation.

Progesterone may interact with certain medications including rifampin, anticonvulsants, and ketoconazole, which can affect its metabolism. It is generally contraindicated in individuals with a history of unexplained vaginal bleeding, active liver disease, or known or suspected hormone-sensitive cancers. Always disclose your full medication list and medical history to your provider.

Doctronic uses an AI-powered evaluation to gather your symptoms and health history, which is then reviewed by a licensed physician. The physician determines whether a prescription refill or treatment plan is appropriate and, if so, sends it directly to your preferred pharmacy.

Yes. Doctronic connects you with fully licensed physicians who are board-certified and state-licensed. All consultations are doctor-reviewed and audited for quality, and the platform is HIPAA-compliant to protect your personal health information.