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Prometrium (micronized progesterone) is primarily prescribed to protect the uterine lining in postmenopausal women who are taking estrogen, and to treat secondary amenorrhea caused by progesterone deficiency. It delivers bioidentical progesterone that closely resembles the hormone produced naturally by the ovaries.

Prometrium is typically taken by mouth, usually once daily in the evening or at bedtime. The dose and duration depend on the indication. For endometrial protection during menopause hormone therapy, a common regimen is 200 mg nightly for 12 days per 28-day cycle, though your physician will tailor the schedule to your needs.

The most commonly reported side effects include drowsiness, dizziness, headache, breast tenderness, bloating, and mood changes. Taking Prometrium at bedtime can help minimize daytime drowsiness. Contact your physician if you experience unusual vaginal bleeding, severe headache, vision changes, or chest pain.

No. Prometrium contains micronized progesterone, which is chemically identical to the progesterone made by the human body. Synthetic progestins such as medroxyprogesterone acetate have a different molecular structure and may have a different side-effect profile. Your physician can help determine which form of progestogen is most appropriate for you.

Generally, women who have had a hysterectomy do not need a progestogen because there is no uterine lining to protect. Prometrium is typically reserved for women who still have their uterus and are taking estrogen therapy. Your physician will review your surgical and medical history before prescribing.

Yes. Prometrium should not be used by individuals with a known or suspected history of breast cancer, active blood clots or thromboembolic disorders, undiagnosed vaginal bleeding, liver disease, or known hypersensitivity to progesterone or peanut oil (the capsule contains peanut oil). A thorough evaluation by your physician is essential before starting therapy.

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