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Mounjaro (tirzepatide) is a once-weekly injectable prescription medication for type 2 diabetes. It activates both GIP and GLP-1 hormone receptors, which stimulates insulin release in response to meals, lowers glucagon levels, and slows the emptying of the stomach. This combination helps reduce blood sugar levels throughout the day.

Unlike medications that target only the GLP-1 receptor, Mounjaro is a dual agonist that also targets the GIP receptor. This dual action is a distinct mechanism and clinical trials have shown it produces significant reductions in HbA1c. Your physician can help determine which medication is the best fit for your individual situation.

Mounjaro is typically initiated at 2.5 mg once weekly for four weeks to improve tolerability, then increased to 5 mg once weekly. Doses may be further escalated in 2.5 mg increments every four weeks as needed and tolerated, up to a maximum of 15 mg once weekly. Your prescribing physician will determine the appropriate dose for you.

The most common side effects reported with Mounjaro are gastrointestinal and include nausea, diarrhea, vomiting, constipation, and decreased appetite. These effects are usually most pronounced when starting the medication or increasing the dose, and tend to improve over time. Contact your provider if side effects are severe or persistent.

Mounjaro is not recommended for people with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). It is also not indicated for type 1 diabetes or diabetic ketoacidosis. Your physician will screen for these and other contraindications during your evaluation.

Mounjaro is injected subcutaneously (under the skin) once weekly using a prefilled single-dose pen. It can be injected into the abdomen, thigh, or upper arm. Your healthcare provider or pharmacist can walk you through the correct injection technique when you receive your prescription.

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