Get Trifluridine Treatment Online

Need a refill of trifluridine eye drops? Doctronic connects you with licensed physicians who can review your history and renew your prescription online, without a clinic visit.


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What Is Trifluridine?

Trifluridine (trifluridine ophthalmic solution) is a prescription antiviral eye drop used to manage herpetic keratitis and keratoconjunctivitis caused by herpes simplex virus types 1 and 2. It works by inhibiting viral DNA synthesis, preventing the virus from replicating in corneal epithelial cells. With the right dosing schedule and ongoing monitoring, most patients experience significant improvement in epithelial healing and symptom relief.

  • Prescription antiviral eye drop proven to treat herpes simplex virus infections of the cornea
  • Get personalized guidance from doctor-trained AI
  • Explore treatment and prescription options

Is Online Trifluridine Treatment Right for You?

Trifluridine refills are appropriate for patients who have a confirmed or previously diagnosed viral eye infection, specifically herpetic keratitis or herpetic keratoconjunctivitis, and who have previously been prescribed trifluridine by a licensed provider. Candidates should have responded to trifluridine therapy without serious adverse reactions such as severe ocular toxicity or hypersensitivity.

Because herpetic eye infections affect the cornea and surrounding ocular structures, your provider will ask about your eye health history, any prior episodes of ocular herpes, current symptoms, and whether you have any conditions affecting your immune system that could influence treatment safety or duration.

  • Diagnosed with herpetic keratitis or herpetic keratoconjunctivitis
  • Get personalized guidance from AI and clinicians
  • Explore treatment and prescription refill options
  • Access care from home, often the same day
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Diagnosed with herpetic keratitis or keratoconjunctivitis Eye redness, tearing, or light sensitivity present Eye pain, irritation, or blurred vision Need a prescription refill Adults 18+ in any U.S. state

How Viral Eye Infection Treatment Works at Doctronic


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Book a $39 telehealth appointment (or copay) within 30 minutes. Our doctors create personalized treatment plans with prescriptions when needed.


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Our doctors prescribe non-controlled medications in all 50 states and send prescriptions to your pharmacy for same-day pickup.

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Chat for free, see an online doctor for $39/visit, or refill a prescription online for as low as $0

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Frequently asked questions

Trifluridine ophthalmic solution is used to treat herpetic keratitis and herpetic keratoconjunctivitis caused by herpes simplex virus types 1 and 2. It is applied directly to the affected eye and works by blocking viral DNA replication in the corneal cells.

Trifluridine is typically instilled as one drop into the affected eye every two hours while awake, up to a maximum of nine drops per day, until the corneal ulcer or erosion has completely healed. Your physician will provide specific instructions tailored to your situation.

Most courses of trifluridine last up to 14 days. Treatment beyond 21 days is generally not recommended due to the risk of ocular toxicity. Your provider will advise you on the appropriate duration based on your response to therapy.

Common side effects include mild burning or stinging upon instillation, temporary blurred vision, eye redness, and increased tearing. Less commonly, ocular toxicity such as corneal epithelial changes can occur with prolonged use. Contact your provider if you experience worsening symptoms or significant discomfort.

You should not wear contact lenses while using trifluridine eye drops during an active herpetic eye infection. The infection itself and the preservatives in the eye drop solution can interact negatively with contact lens wear. Ask your provider when it is safe to resume lens use.

Trifluridine is used for acute episodes rather than for long-term suppression. If you experience frequent recurrences, your provider may consider oral antiviral therapy such as valacyclovir for suppressive treatment. Discuss your history of recurrences with your physician during your online visit.

The safety of trifluridine during pregnancy and breastfeeding has not been fully established. Because ocular absorption into the bloodstream is minimal, risk is considered low, but you should inform your Doctronic physician if you are pregnant, planning to become pregnant, or breastfeeding so they can make the best recommendation for your situation.

Doctronic uses an AI-guided evaluation to collect your medical history and symptoms, which is then reviewed by a licensed physician. If appropriate, the physician issues a treatment plan or prescription refill. The entire process is HIPAA-compliant and handled by real, licensed doctors.