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Regranex (becaplermin) is a recombinant human platelet-derived growth factor (PDGF-BB) formulated as a 0.01% topical gel. It works by binding to PDGF receptors on wound cells, stimulating the migration and multiplication of the cells needed for tissue repair. This helps accelerate closure of diabetic neuropathic ulcers that reach below the skin surface.

Regranex gel is applied once daily in a thin, continuous layer that covers the entire ulcer surface. After 12 hours, the gel and any residue are rinsed away with saline or water, and a moist dressing is reapplied without the gel for the remaining 12 hours. Your physician will calculate the correct amount to apply based on the size of your wound.

The FDA has issued a boxed warning noting that patients who used three or more tubes of Regranex (becaplermin) had a higher rate of cancer-related death compared with those who used fewer tubes in a retrospective study. Regranex should not be used in patients with known malignancy at or near the application site, and your physician will carefully weigh the risks and benefits, especially for patients with a history of cancer.

Clinical studies showed that more patients achieved complete wound closure with Regranex plus good wound care compared with wound care alone, with meaningful improvements typically assessed at 20 weeks. Individual results depend on wound size, depth, blood supply, glycemic control, and consistent wound care practices.

No. Regranex is specifically approved for lower-extremity diabetic neuropathic ulcers that extend into the subcutaneous tissue or beyond and have an adequate blood supply. It is not indicated for pressure ulcers, venous stasis ulcers, wounds in patients with ischemia, or wounds with active infection that has not been treated.

Good wound care is essential for Regranex to be effective. This includes regular debridement of necrotic tissue, keeping the wound moist with appropriate dressings, offloading pressure from the affected foot, controlling blood glucose levels, and monitoring for signs of infection. Regranex is a complement to, not a replacement for, these fundamental practices.

Doctronic uses an AI-powered evaluation to gather your medical history, wound details, and relevant health information. A licensed physician then reviews your case, makes a clinical determination, and if appropriate, creates a personalized treatment plan that may include a prescription sent to your pharmacy.

Yes. Doctronic works exclusively with licensed physicians who are board-certified in their specialties. All consultations are doctor-reviewed, regularly audited for quality, and fully HIPAA-compliant to protect your personal health information. Doctronic is available to adults 18 and older in any U.S. state.