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Zurampic (lesinurad) is a prescription uric acid lowering medication that works by blocking two kidney transporters, URAT1 and OAT4, which are responsible for reabsorbing uric acid back into the bloodstream. By inhibiting these transporters, lesinurad helps the kidneys excrete more uric acid, lowering serum uric acid levels in patients with gout.

No. Zurampic must be used in combination with a xanthine oxidase inhibitor such as allopurinol or febuxostat. When taken alone, lesinurad has been associated with a higher risk of kidney-related side effects including acute kidney injury. Doctronic physicians will evaluate whether you are already on or are a candidate for a xanthine oxidase inhibitor before prescribing.

The most serious risk associated with Zurampic is acute kidney injury, which is why it must be taken with a xanthine oxidase inhibitor and why regular kidney function monitoring is recommended. Other reported side effects include headache, influenza, elevated serum creatinine, and gastroesophageal reflux disease. Tell your doctor about any history of kidney problems before starting treatment.

Serum uric acid levels can begin to fall within a few weeks of starting Zurampic, but reaching and sustaining the target level, typically below 6 mg/dL, may take several months. Gout flares may temporarily increase when urate-lowering therapy is first started as uric acid crystals begin to dissolve, so your physician may recommend a flare prophylaxis medication during this period.

The approved dose of Zurampic is 200 mg taken orally once daily in the morning with food and water. It should always be taken at the same time as your xanthine oxidase inhibitor. Patients with severe kidney impairment should not take Zurampic. Your physician will review your kidney function before and during treatment.

Yes. Zurampic has several important drug interactions. Aspirin at doses above 325 mg per day and certain other medications that compete with the same kidney transporters may affect how lesinurad works. Some common medications, including certain statins and hormonal contraceptives, may have reduced effectiveness when taken with lesinurad. Always provide your physician with a complete medication list.

Doctronic uses an AI-guided evaluation to gather a thorough picture of your symptoms, medical history, and current medications. A licensed physician then reviews your information, determines whether treatment is appropriate for you, and creates a personalized treatment plan. The entire process is designed to be convenient, thorough, and clinically rigorous.

Yes. Doctronic connects you with licensed physicians who are authorized to practice in your state. All consultations are doctor-reviewed, and our platform is HIPAA-compliant to protect your personal health information. Doctronic is available to adults 18 and older in any U.S. state.