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Diflucan (fluconazole) is used to treat yeast infections caused by Candida species, including vaginal yeast infections (vaginal candidiasis), oral thrush (oropharyngeal candidiasis), and esophageal candidiasis. It can also be used to prevent yeast infections in people with weakened immune systems.

Fluconazole works by blocking the fungal enzyme lanosterol 14-alpha-demethylase, which the fungus needs to produce ergosterol, a critical component of the fungal cell membrane. Without ergosterol, the fungal cell membrane becomes unstable and the fungus cannot survive or reproduce.

For an uncomplicated vaginal yeast infection, the standard dose is a single 150 mg oral tablet. For recurrent or more severe infections, a physician may prescribe multiple doses or a longer course. Always follow your prescribing doctor's instructions.

Most people begin to notice symptom improvement within 24 hours of taking a single dose of Diflucan. Full resolution of symptoms typically occurs within 3 to 7 days. If symptoms do not improve or worsen after a few days, contact your provider.

Yes. Fluconazole can interact with several medications, including warfarin, certain statins, some diabetes medications, and drugs that affect heart rhythm. It inhibits the liver enzyme CYP2C9 and CYP3A4, which can increase the blood levels of many other drugs. Always inform your provider of all medications you are taking.

Diflucan should not be taken by people with a known allergy to fluconazole or other azole antifungals. It is generally not recommended during pregnancy, especially at higher doses, due to potential risk to the fetus. People with liver disease or certain heart rhythm conditions should use it with caution and only under a doctor's supervision.

The most commonly reported side effects of a single-dose fluconazole include headache, nausea, abdominal pain, and diarrhea. Serious side effects such as liver toxicity or severe skin reactions are rare but can occur, particularly with higher doses or longer treatment courses. Contact your provider if you experience yellowing of the skin, dark urine, or a rash.

Doctronic uses an AI-powered evaluation to gather your symptom history and health information. A licensed physician then reviews your case and, if appropriate, provides a personalized treatment plan that may include a prescription sent to your preferred pharmacy. The entire process is HIPAA-aligned and designed to be fast and convenient.