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Vyzulta (latanoprostene bunod) is a prescription eye drop that releases two active molecules when it contacts the eye: latanoprost acid and butanediol mononitrate. Latanoprost acid increases fluid drainage through the uveoscleral pathway, while butanediol mononitrate donates nitric oxide to relax the trabecular meshwork, providing a second drainage route. Together, they lower intraocular pressure more effectively than either mechanism alone.

The standard dose is one drop of Vyzulta instilled into the affected eye or eyes once daily in the evening. Consistent evening dosing is important for maintaining stable pressure control. If you wear contact lenses, remove them before applying the drop and wait at least 15 minutes before reinserting them.

The most frequently reported side effect is conjunctival hyperemia, or eye redness, which occurs in a significant portion of users. Other possible effects include eye irritation or pain upon instillation, growth of eyelashes, darkening of the iris (which may be permanent), and darkening of the skin around the eye. Serious reactions are uncommon but should be reported to your physician promptly.

Yes. Like other prostaglandin analogs, Vyzulta can cause increased pigmentation of the iris over time, particularly in eyes with mixed coloring such as hazel or blue-brown. This change is gradual and may be permanent even after stopping the medication. It does not affect vision but should be discussed with your physician before starting treatment.

Vyzulta should be used with caution in patients with a history of intraocular inflammation (uveitis), macular edema, or those who are aphakic (lacking a natural lens). Your physician will review your full ocular history before prescribing to ensure the medication is appropriate and safe for your specific situation.

Both medications are prostaglandin-based eye drops, but Vyzulta adds a nitric oxide-donating component that targets the trabecular meshwork in addition to the uveoscleral pathway. Clinical trials have shown Vyzulta to produce slightly greater IOP reductions compared to latanoprost alone, making it a useful option for patients who need additional pressure control.

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Yes. Doctronic connects patients with fully licensed physicians who are authorized to practice in your state. Every treatment decision is doctor-reviewed and held to the same clinical standards as an in-person visit. The platform is HIPAA-compliant, and all patient information is kept private and secure. Doctronic is available to adults 18 and older in any U.S. state.