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Jardiance (empagliflozin) is approved to improve blood sugar control in adults with type 2 diabetes. It is also approved to reduce the risk of cardiovascular death in adults with type 2 diabetes who have established heart disease. It is not indicated for type 1 diabetes.

Jardiance works by inhibiting the SGLT2 transporter in the kidneys. This transporter normally reabsorbs glucose back into the bloodstream. By blocking it, Jardiance causes excess glucose to be excreted in the urine, lowering blood sugar levels. It also produces modest reductions in blood pressure and body weight.

Common side effects include genital yeast infections, urinary tract infections, increased urination, and low blood pressure, particularly in patients on diuretics or with reduced kidney function. Less commonly, Jardiance can cause diabetic ketoacidosis. Talk to your provider about all side effects before starting treatment.

Jardiance is not recommended for people with severe kidney impairment, end-stage renal disease, or those on dialysis, as it requires adequate kidney function to work. It should not be used in patients with type 1 diabetes. Your physician will review your full medical history to confirm it is appropriate for you.

Some people experience modest weight reduction while taking Jardiance, primarily because excess glucose and calories are excreted in the urine. However, Jardiance is not a weight-loss medication and any weight change varies between individuals.

Yes, Jardiance is often prescribed alongside other diabetes medications such as metformin, insulin, or DPP-4 inhibitors. However, combining it with insulin or insulin secretagogues may increase the risk of low blood sugar. Your physician will review your current regimen and adjust as needed.

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