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Januvia works by inhibiting the DPP-4 enzyme. This prevents the breakdown of incretin hormones, which in turn stimulates insulin release from the pancreas and suppresses glucagon secretion in a glucose-dependent manner. The result is lower blood sugar levels, particularly after meals.

When used alone, Januvia has a low risk of causing hypoglycemia because it only stimulates insulin release when blood sugar is elevated. However, the risk increases if Januvia is combined with other diabetes medications such as sulfonylureas or insulin, and dose adjustments may be necessary.

Januvia begins lowering blood sugar within a few days of starting treatment, but meaningful reductions in A1C are typically seen after 12 to 24 weeks of consistent use. Your physician will monitor your response over time and adjust your plan accordingly.

Yes. Januvia is frequently prescribed alongside metformin, SGLT-2 inhibitors, or insulin as part of a combination approach to blood sugar control. Your physician will review your full medication list to ensure safety and avoid interactions.

Yes. Sitagliptin is cleared by the kidneys, so dosing must be adjusted for patients with moderate or severe chronic kidney disease. Your physician will take your kidney function into account when determining whether Januvia is appropriate and at what dose.

Serious but uncommon side effects include pancreatitis, severe joint pain (arthralgia), and a serious skin condition called bullous pemphigoid. Seek medical attention if you develop severe abdominal pain, blistering skin, or unusual joint pain while taking Januvia.

Doctronic uses an AI-powered evaluation to gather your health history and symptoms. A licensed physician then reviews your information, makes a clinical determination, and, if appropriate, provides a personalized treatment plan that may include a prescription.

Yes. Doctronic connects you with licensed physicians who are doctor-reviewed, audited for quality, and operate in full compliance with HIPAA privacy standards. Our platform is designed to provide safe, evidence-based care for adults 18 and older across all U.S. states.