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Cortef is the brand name for oral hydrocortisone, a corticosteroid that replaces cortisol in people whose adrenal glands do not produce enough of it. It is primarily prescribed for adrenal insufficiency, including Addison's disease and secondary adrenal insufficiency caused by pituitary or hypothalamic disorders.

Cortef is usually taken two to three times daily, with the largest dose given in the morning to mimic the body's natural cortisol peak. Your physician will determine the appropriate dose based on your weight, lab results, and clinical response. Doses often need to be temporarily increased during illness, surgery, or other physical stress.

People taking Cortef for adrenal insufficiency should double or triple their daily dose during periods of significant physical stress such as fever, illness, or surgery. Failure to do so can lead to an adrenal crisis, which is a life-threatening emergency. Your prescribing physician will provide specific guidance on sick-day dosing.

At physiologic replacement doses, side effects are generally minimal. However, higher doses or long-term use can cause weight gain, elevated blood sugar, insomnia, mood changes, increased blood pressure, and bone density loss. Regular follow-up and monitoring help minimize these risks.

No. Cortef should never be stopped suddenly without medical guidance, especially if you have been taking it for an extended period. Abrupt discontinuation can trigger adrenal insufficiency symptoms or an adrenal crisis. Your physician will provide a tapering plan if discontinuation is appropriate.

Yes. Cortef can interact with several medications, including drugs that affect liver enzymes (such as rifampin and certain antiseizure medications), blood thinners, diabetes medications, and NSAIDs. Always inform your physician about all medications and supplements you take.

Doctronic uses an AI-guided evaluation to gather your symptoms, medical history, and relevant information before connecting you with a licensed physician. The physician reviews your case, makes a clinical determination, and creates a personalized treatment plan, which may include a prescription when medically appropriate.

Yes. Doctronic works exclusively with licensed physicians whose consultations are doctor-reviewed and audited for quality. The platform is HIPAA-compliant, protecting your personal health information. Doctronic is available to adults 18 and older in any U.S. state.