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Clobetasol propionate is indicated for severe inflammatory and pruritic skin conditions that are responsive to corticosteroids, including plaque psoriasis, severe atopic dermatitis (eczema), lichen planus, lichen sclerosus, and other conditions where lower-potency steroids have not been effective.

Because clobetasol is an ultra-high-potency corticosteroid, treatment is generally limited to two weeks at a time, with a maximum of 50 grams per week for most formulations. Prolonged use can cause skin thinning, stretch marks, and systemic absorption effects. Your physician will guide you on the safest duration for your situation.

Clobetasol should not be applied to the face, groin, or axillae (underarms) unless specifically directed by your physician, as skin in these areas is thinner and at higher risk for side effects. It should also be kept away from the eyes and should not be used on skin with an active bacterial, fungal, or viral infection.

Common side effects include burning or stinging at the application site, skin thinning (atrophy), stretch marks, and temporary skin discoloration with prolonged use. Systemic effects such as adrenal suppression are possible with extensive use or occlusive dressings, and your physician will monitor for these.

Using clobetasol under occlusive dressings or bandages significantly increases the absorption of the medication and raises the risk of systemic side effects. You should not cover treated areas unless your physician specifically instructs you to do so.

Clobetasol should be used during pregnancy or breastfeeding only if the potential benefit justifies the potential risk. Potent topical corticosteroids have been associated with fetal growth restriction when used in large amounts. Discuss your situation with a physician before continuing or starting clobetasol if you are pregnant or breastfeeding.

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