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Mental Health

Can You Take Advil with Zoloft?

Andre Stone | MD

Medically reviewed by Andre Stone | MD, University of Pittsburgh School of Medicine on August 25th, 2026.

Advil (ibuprofen) and Zoloft (sertraline) can sometimes be taken together, but the combination can increase the risk of bleeding, particularly in the stomach or intestines. Ask a healthcare professional before combining them if you have bleeding risk factors, and use the lowest effective ibuprofen dose for the shortest necessary time. This risk occurs because both medications can affect blood clotting mechanisms - SSRIs like Zoloft reduce platelet function while NSAIDs like Advil can irritate the stomach lining. Studies suggest that taking an SSRI with an NSAID can raise the risk of gastrointestinal bleeding, although the size of the increase varies among studies and depends on a person’s other risk factors. If you use the combination, seek urgent medical care for vomiting blood, black or bloody stools, unusual bleeding or bruising, severe weakness, fainting, or severe stomach pain. Consult a healthcare professional before use if you need ibuprofen regularly, have had an ulcer or gastrointestinal bleeding, or take medicines that increase bleeding risk.

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