Mental Health

Does Celexa Cause Less Weight Gain than Lexapro?

Linda Girgis | MD

Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 20th, 2026.

Yes, Celexa typically causes less weight gain than Lexapro based on clinical studies. Research shows that citalopram (Celexa) is associated with minimal weight changes, while escitalopram (Lexapro) can cause weight gain in 1-10% of patients during the first 6 months of treatment. Both medications are selective serotonin reuptake inhibitors (SSRIs), but they affect metabolism differently due to their distinct chemical structures. Individual responses vary significantly, with some patients experiencing no weight changes on either medication. Weight gain typically occurs gradually and ranges from 2-10 pounds when it does happen. Your healthcare provider can monitor your weight and adjust treatment if significant changes occur.

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