Does Prozac Make You Gain Weight?

Prozac (fluoxetine) typically causes weight loss rather than weight gain in most patients. Clinical studies show that patients taking Prozac lose an average of 2-10 pounds during the first six months of treatment. This occurs because fluoxetine suppresses appetite and increases serotonin levels, which can reduce food cravings. However, some patients may experience weight gain after long-term use, particularly if they regain their appetite as depression symptoms improve. The weight effects vary significantly between individuals, with factors like dosage, duration of treatment, and personal metabolism playing important roles. Most healthcare providers monitor weight changes during the first few months of treatment.