Can You Take St. John''s Wort with Antidepressants?
Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 20th, 2026.
No, you should not take St. John's Wort with antidepressants due to serious drug interactions. Combining these substances can cause serotonin syndrome, a potentially life-threatening condition that occurs when serotonin levels become dangerously high. St. John's Wort affects the same brain pathways as many prescription antidepressants, including SSRIs, SNRIs, and tricyclics. Studies show that concurrent use increases serotonin syndrome risk by up to 300%. The herb also reduces the effectiveness of many medications by speeding up their metabolism through liver enzymes. Always consult your healthcare provider before stopping antidepressants or adding any herbal supplements to avoid withdrawal symptoms or dangerous interactions.
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