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Hyzaar contains losartan, an angiotensin II receptor blocker (ARB), and hydrochlorothiazide, a thiazide diuretic. Losartan prevents a hormone called angiotensin II from tightening blood vessels, while hydrochlorothiazide helps the kidneys remove excess sodium and water. Together they lower blood pressure through two different pathways.

Hyzaar is typically prescribed for adults whose blood pressure is not well controlled on a single medication, and for those who have been taking losartan and hydrochlorothiazide separately and find a combination pill more convenient. It is also indicated to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy.

Common side effects include dizziness, especially when standing up quickly, upper respiratory infections, back pain, and fatigue. Hydrochlorothiazide can lower potassium levels, so your physician may periodically check blood tests. Contact your doctor if you experience significant muscle weakness, irregular heartbeat, or swelling of the face or throat.

Hyzaar requires careful consideration in patients with kidney disease, as ARBs and diuretics can affect kidney function and electrolyte balance. It may still be appropriate in many cases. Your physician will review your kidney function, potassium levels, and other health conditions before prescribing Hyzaar.

Hyzaar is not safe during pregnancy. ARBs like losartan can cause serious harm or death to a developing fetus, particularly in the second and third trimesters. Women who are pregnant or planning to become pregnant should not take Hyzaar and should discuss alternative blood pressure treatments with their physician immediately.

Yes. Hyzaar can interact with potassium supplements, potassium-sparing diuretics, NSAIDs such as ibuprofen, lithium, and certain diabetes medications. NSAIDs may reduce Hyzaar's blood pressure-lowering effect and increase kidney risk. Always provide your physician with a complete list of your current medications and supplements.

Doctronic uses an AI-guided evaluation to gather detailed information about your symptoms, health history, and current medications. A licensed physician then reviews your case, makes a clinical determination, and, if appropriate, creates a personalized treatment plan that may include a prescription sent to your preferred pharmacy.

Yes. Doctronic connects you with real, licensed physicians who review every case individually. All consultations are HIPAA-compliant, and prescribing decisions are doctor-reviewed and audited to meet clinical standards. Doctronic is available to adults 18 and older in any U.S. state.