Medically reviewed by Lauren Okafor | MD, The Frank H Netter MD School of Medicine, Loyola University Medical Center on March 13th, 2026.
A recent study suggests a potential link between Depo-Provera and meningiomas
The risk appears to be extremely low, with only 5 in 10,000 women potentially affected
Birth control options remain safe and effective
Consulting a healthcare provider is crucial for personalized medical advice
Birth control is an important part of reproductive healthcare, and the Depo-Provera shot has been a widely used contraceptive for many years. Recently, a study raised questions about a possible link between this contraceptive and certain brain tumors called meningiomas. While this may sound concerning, it’s important to understand the research and the actual level of risk.
Meningiomas are usually benign (noncancerous) tumors that grow in the membranes surrounding the brain and spinal cord. The French national study that brought attention to this topic examined several types of progestin-based medications, including the hormone used in Depo-Provera.
Depo-Provera is an injectable contraceptive that prevents pregnancy in several ways:
It stops ovulation, meaning the ovaries do not release an egg.
It thickens cervical mucus, which helps block sperm from reaching an egg.
It thins the uterine lining, making implantation less likely.
The injection is given once every three months, and when used correctly it is about 96% effective at preventing pregnancy.
The study that raised concerns analyzed about 18,000 patients diagnosed with intracranial meningiomas. However, only nine of those patients had used intramuscular medroxyprogesterone, the active ingredient in Depo-Provera.
Because this number is so small, researchers cannot draw firm conclusions about whether Depo-Provera actually causes meningiomas. More research is needed to understand whether a real connection exists.
Based on the available data, the overall risk appears very low:
About 5 out of 10,000 women using medroxyprogesterone may develop a meningioma.
About 1 out of 10,000 women not using the medication may develop a similar tumor.
More than 2,300 people would need to use the medication for one additional associated case.
These numbers suggest that while a possible association is being studied, the absolute risk remains small.
If you use Depo-Provera or are considering it, the best step is to talk with your healthcare provider. They can help you weigh the benefits and potential risks based on your personal health history and contraceptive needs.
Contraceptive Method |
Meningioma Risk |
Pregnancy Prevention |
|---|---|---|
Depo-Provera |
Very Low |
96% Effective |
No Contraception |
Similar Low Risk |
0% Protection |
Other Hormonal Methods |
Varies |
91-99% Effective |
Medical professionals emphasize that the risks of an unplanned pregnancy far outweigh the potential rare risk of a meningioma. Birth control alternatives are available for those concerned about this specific risk.
Yes, it remains a safe and effective birth control option for most women.
Most meningiomas are benign and slow-growing, with many requiring no immediate treatment.
Consult your healthcare provider for personalized medical advice.
Symptoms can include headaches, vision changes, and neurological symptoms.
Multiple options exist, including pills, IUDs, and barrier methods.
While the study raises interesting questions, it does not definitively prove a significant risk. Every contraceptive method has potential side effects, and individual health considerations are crucial. Care you can trust. Doctronic is clinically validated with 99% treatment plan alignment.
What an Anxiety Attack Actually IsAn anxiety attack is a sudden episode of intense anxiety or fear accompanied by physical symptoms including racing heart, shortness of [...]
Read MoreWhy People Look Beyond PrescriptionsDepression is one of the most common mental health conditions in the United States. About 67% of adults who experienced a major depressive [...]
Read MoreDepression Is Not a Linear ProgressionDepression does not progress through a fixed, predictable sequence of stages the way some medical conditions do. The term [...]
Read More
Join 50,000+ readers using Doctronic to understand symptoms, medications,
and next steps.
Add your phone number below to get health updates and exclusive VIP offers.
By providing your phone number, you agree to receive SMS updates from Company. Message and data rates may apply. Reply “STOP” to opt-out anytime. Read our Privacy Policy and Terms of Service for more details.
Save your consults. Talk with licensed doctors and manage your health history.
