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Read MoreMedically reviewed by Alan Lucks | MD, Alan Lucks MDPC Private Practice - New York on December 2nd, 2025.
Tendon rupture occurs in approximately 3.2 per 1,000 patients, typically affecting the Achilles tendon within 48 hours of starting treatment or up to 6 months after discontinuation.
Peripheral neuropathy can develop within days and may become permanent in some patients, causing burning, tingling, numbness, or weakness in hands and feet.
Patients over 60 have a 3-4 times higher risk of serious complications, especially when combined with corticosteroids like prednisone or prednisolone.
C. difficile-associated diarrhea develops in 10-25% of patients and can occur weeks after completing the antibiotic course, potentially becoming life-threatening.
QT interval prolongation on ECG increases risk of dangerous heart rhythm abnormalities, particularly in patients with existing heart conditions or electrolyte imbalances.
Levaquin is a widely prescribed antibiotic used to treat a variety of bacterial infections. While it can be very effective, like all medications, it comes with potential side effects. Understanding these side effects helps you stay informed and know when to seek help. This article breaks down nine common and serious side effects of Levaquin, what causes them, and how to manage them safely.
Nausea is one of the most common side effects of Levaquin. It happens because the antibiotic can irritate your stomach lining. You might also experience mild stomach pain or diarrhea. These symptoms usually appear within the first few days of treatment and often improve as your body adjusts.
To reduce nausea, take Levaquin with food unless your doctor advises otherwise. Staying hydrated and eating small, bland meals can also help soothe your stomach.
Some people taking Levaquin report headaches or dizziness. These side effects occur because the medication can affect your nervous system. While usually mild, dizziness can increase the risk of falls, so it’s important to be cautious when standing or walking.
If you feel dizzy, avoid driving or operating heavy machinery until you know how Levaquin affects you. Drinking plenty of water and resting can ease headaches.
Levaquin has been linked to tendon problems, including pain, swelling, and in rare cases, tendon rupture. This side effect is more common in older adults and people taking corticosteroids. Tendon issues can happen during or even months after finishing the medication.
Stop using Levaquin and contact your doctor immediately if you notice sudden tendon pain, especially in the Achilles tendon at the back of your ankle. Early treatment can prevent more serious damage.
Some patients experience numbness, tingling, or a “pins and needles” feeling, especially in the hands or feet. This happens because Levaquin can affect nerve function. If these symptoms appear, they may be early signs of nerve damage.
Tell your healthcare provider right away if you feel these sensations. Stopping the medication early may prevent permanent nerve problems.
Levaquin can make your skin more sensitive to sunlight, increasing the risk of sunburn. This happens because the drug increases your skin’s reaction to UV rays. You might notice redness, itching, or blistering after sun exposure.
Wear protective clothing and use a broad-spectrum sunscreen when outdoors. Avoid tanning beds and prolonged sun exposure while taking Levaquin.
Antibiotics like Levaquin can disrupt the natural balance of bacteria in your gut, sometimes causing diarrhea. In rare cases, this can lead to a serious condition called Clostridium difficile colitis, which causes severe diarrhea and requires immediate medical attention.
If you develop watery or bloody diarrhea, fever, or stomach cramps, contact your doctor right away. Do not stop your medication without medical advice.
Some people report feeling anxious, confused, or having trouble sleeping while on Levaquin. These side effects are less common but can be distressing. They may be related to the drug’s impact on the brain and nervous system.
If you notice mood changes or insomnia, discuss these symptoms with your healthcare provider. Adjusting your dosage or switching medications might be necessary.
Though rare, Levaquin can cause liver damage. Symptoms include yellowing of the skin or eyes (jaundice), dark urine, and severe stomach pain. Liver problems require urgent medical care.
Regular blood tests may be recommended if you take Levaquin for a long time or have a history of liver issues.
Allergic reactions to Levaquin can range from mild rashes to life-threatening anaphylaxis. Signs include hives, swelling of the face or throat, difficulty breathing, and severe dizziness.
If you experience any of these symptoms, seek emergency medical care immediately.
How to Manage and Reduce Side Effects of LevaquinFollow your doctor’s instructions carefully. Taking Levaquin exactly as prescribed helps reduce side effects and improve effectiveness. Avoid skipping doses or stopping the medication early without medical advice.
Drinking plenty of water and eating balanced meals can ease stomach upset and help your body handle the medication better. Avoid alcohol, which can increase side effects and harm your liver.
Wear sunscreen and protective clothing when outdoors. Avoid tanning beds and limit sun exposure to prevent photosensitivity reactions.
Keep track of any new or worsening symptoms. If you experience severe side effects like tendon pain, numbness, or allergic reactions, contact your healthcare provider immediately.
Allergic reactions are serious and require immediate attention. Even if you have taken Levaquin before without problems, allergies can develop later. Inform your doctor about any previous reactions to antibiotics or other medications.
Levaquin should be used cautiously in people with a history of seizures, kidney problems, or heart rhythm issues. Always provide your full medical history to your healthcare provider before starting this medication.
Not all side effects require emergency care, but some do. Call your doctor or seek urgent care if you experience:
Sudden tendon pain or swelling
Numbness or tingling in your limbs
Severe diarrhea or bloody stools
Yellowing of your skin or eyes
Difficulty breathing or swelling of your face/throat
Severe dizziness or confusion
For quick and convenient medical advice, consider using Doctronic.ai. Their AI-powered platform offers personalized care and can help you understand your symptoms and next steps without waiting for an in-person visit.
Doctronic is an AI doctor that uses the latest medical research to provide fast, personalized answers about medications like Levaquin. Whether you want to understand side effects, get treatment advice, or seek a second opinion, Doctronic is available 24/7 with telehealth video visits under $40 in all 50 states.
With over 10 million users, Doctronic offers care that remembers your history and tailors recommendations just for you. Visit Doctronic.ai to get started and have your health questions answered in seconds.
Levaquin is a powerful antibiotic that can treat serious infections effectively. Being aware of its side effects helps you stay safe and get the best results. Mild symptoms like nausea or headache often pass quickly, but serious issues like tendon pain or allergic reactions need prompt care.
Doctronic.ai can make managing your health easier. Their AI-driven platform offers quick, personalized medical support whenever you need it.
Yes, some side effects like tendon damage or nerve problems can last long after treatment ends. Early detection and stopping the medication can reduce risks.
Levaquin dosage may need adjustment if you have kidney issues. Always inform your doctor about any kidney disease before starting treatment.
Take the missed dose as soon as you remember, unless it's close to the next dose. Do not double up to catch up.
Alcohol can increase side effects and stress your liver. It's best to avoid alcohol during treatment.
Severe pain, difficulty breathing, swelling, or changes in consciousness require immediate medical attention.
Stop taking Levaquin immediately and seek emergency care for tendon pain, swelling, or difficulty walking, as continued use after tendon symptoms begin dramatically increases rupture risk. Monitor for nerve symptoms like numbness or burning sensations, which require prompt evaluation to prevent permanent damage. If you're experiencing concerning symptoms while taking this antibiotic, Doctronic can provide quick medical guidance to help determine your next steps.
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