8 Common and Serious Side Effects of Ciprofloxacin

Alan Lucks | MD

Medically reviewed by Alan Lucks | MD, Alan Lucks MDPC Private Practice - New York on December 3rd, 2025.

Key Takeaways

  • Ciprofloxacin treats many infections but may cause side effects ranging from mild to serious.

  • Common side effects include nausea, diarrhea, and dizziness.

  • Some serious side effects, like tendon problems or nerve issues, require immediate medical attention.

  • Knowing when to contact a healthcare provider is important for your safety.

  • Doctronic.ai offers quick, affordable telehealth visits to discuss side effects and get personalized advice.

Understanding Ciprofloxacin Side Effects

Ciprofloxacin is a powerful antibiotic used to treat various infections. While it can be very effective, it also comes with some side effects that you should know about. Understanding these can help you stay safe and get the best results from your treatment.

1. Nausea and Upset Stomach

Nausea is one of the most common side effects of Ciprofloxacin. It happens because the antibiotic can irritate your stomach lining. You might also feel bloated or have an upset stomach. These symptoms usually start soon after taking the medicine and can last a few days.

To reduce nausea, try taking Ciprofloxacin with food or a full glass of water. Avoid heavy or spicy meals until your stomach feels better. If nausea is severe or lasts more than a week, it’s important to talk to a doctor.

2. Diarrhea

Diarrhea is another frequent side effect. Antibiotics like Ciprofloxacin can upset the balance of good bacteria in your gut, leading to loose or watery stools. Mild diarrhea often resolves after finishing the medication.

Drink plenty of fluids to stay hydrated and eat bland foods like bananas, rice, and toast. If diarrhea is severe, contains blood, or lasts longer than a few days, seek medical advice immediately.

3. Dizziness and Lightheadedness

Some people experience dizziness or feel lightheaded while taking Ciprofloxacin. This can happen because the drug affects your nervous system or blood pressure. It’s usually mild but can make activities like driving or operating machinery unsafe.

If dizziness occurs, sit or lie down until it passes. Avoid alcohol and other sedatives as they can increase this effect. If dizziness is severe or leads to fainting, contact your healthcare provider right away.

4. Tendon Pain and Risk of Tendon Rupture

This is one of the more serious side effects. Ciprofloxacin can weaken tendons, especially in the Achilles tendon behind your ankle. You might feel pain, swelling, or stiffness in a tendon area. This risk is higher for older adults and people who take steroids.

If you notice tendon pain or difficulty moving a joint, stop the medication and get medical help immediately. Early treatment can prevent tendon rupture, which might require surgery.

5. Nerve Damage (Peripheral Neuropathy)

Peripheral neuropathy means damage to the nerves outside your brain and spinal cord. Ciprofloxacin can cause symptoms like tingling, numbness, burning, or weakness in your hands or feet. These symptoms can start quickly and sometimes last a long time.

If you experience any nerve symptoms, tell your doctor right away. Early diagnosis can help reduce long-term effects. Avoid activities that could cause injury if you have numbness or weakness.

6. Changes in Mood or Behavior

Some patients report feeling anxious, confused, or depressed while on Ciprofloxacin. These changes can be mild or more serious, including hallucinations or suicidal thoughts in rare cases. The exact cause isn’t fully understood, but it may relate to how the drug interacts with the brain.

If you or someone you know experiences mood changes, seek medical advice quickly. Mental health symptoms should always be taken seriously.

7. Photosensitivity (Sun Sensitivity)

Ciprofloxacin can make your skin more sensitive to sunlight. This means you might get sunburned more easily, even after short sun exposure. The reaction can cause redness, itching, or blistering.

To protect yourself, wear sunscreen, hats, and protective clothing when outdoors. Avoid tanning beds and prolonged sun exposure during treatment and for a few days after finishing Ciprofloxacin.

8. Headache

Headaches are a common side effect, but usually mild. They can occur because Ciprofloxacin affects the nervous system or causes dehydration if you have diarrhea or nausea.

Drink plenty of water and rest when you have a headache. Over-the-counter pain relievers can help, but check with your doctor if headaches are severe or persistent.

White tablets spilled from an open pill bottle onto a smooth surface.How to Manage and Reduce Side Effects of Ciprofloxacin

Take Ciprofloxacin With Food and Water

Eating a light meal and drinking a full glass of water when taking Ciprofloxacin can reduce stomach upset and nausea. Avoid dairy products close to your dose as they can affect how the drug works.

Stay Hydrated

Drinking plenty of fluids helps prevent headaches and diarrhea-related dehydration. Water also supports your body in handling the medication better.

Protect Yourself From the Sun

Use sunscreen and wear protective clothing to avoid photosensitivity reactions. Limit your time in direct sunlight during treatment.

Report Serious Symptoms Early

Don’t wait; if you notice tendon pain, nerve symptoms, or mood changes. Early medical help can prevent complications and improve outcomes.

Ciprofloxacin Allergic Reactions and Warnings

Some people may have an allergic reaction to Ciprofloxacin. Signs include rash, itching, swelling of the face or throat, difficulty breathing, or severe dizziness. These symptoms require emergency medical attention.

Also, Ciprofloxacin is not suitable for everyone. People with a history of tendon problems, certain heart problems such as aortic conditions, myasthenia gravis or allergies to similar antibiotics should avoid it. Always tell your healthcare provider about your medical history before starting Ciprofloxacin.

When to Contact Your Doctor About Ciprofloxacin Side Effects

While many side effects are mild and go away on their own, some require prompt medical attention. Contact your doctor if you experience:

  • Severe tendon pain or swelling

  • Numbness, tingling, or weakness in your limbs

  • Signs of an allergic reaction, such as rash or difficulty breathing

  • Severe diarrhea with blood or dehydration

  • Confusion, hallucinations, or suicidal thoughts

For quick and affordable medical advice, consider using Doctronic.ai. Their AI-powered doctor visits provide personalized answers and can connect you with licensed doctors 24/7 in all 50 states.

Learn More About Ciprofloxacin Side Effects With Doctronic

Understanding how Ciprofloxacin might affect you personally is important. Doctronic.ai offers AI-powered doctor visits that use the latest medical research to provide tailored information about side effects and how to manage them. You can get answers in seconds and schedule affordable video visits with real doctors anytime.

The Bottom Line About Ciprofloxacin Side Effects

Ciprofloxacin is an effective antibiotic, but knowing its side effects can protect your health. Most side effects are manageable with simple steps like taking the medicine with food and staying hydrated. Severe symptoms, such as tendon pain or nerve issues, require prompt medical attention.

For personalized guidance and easy access to medical care, Doctronic.ai offers AI-powered doctor visits that combine the latest medical knowledge with real human care. Millions have trusted Doctronic for fast, smart, and personal healthcare support.

Frequently Asked Questions

Mild dizziness can happen. Sit or lie down until it passes, and avoid driving or heavy tasks. If dizziness is severe or persistent, contact your doctor.

Yes, Ciprofloxacin can increase the risk of tendon rupture, especially in older adults or those on steroids. Seek immediate medical care if you feel tendon pain or swelling.

Most mild side effects, like nausea last a few days after starting treatment. Serious side effects may require longer recovery or medical intervention.

Stop taking the medication and get emergency medical help immediately if you experience rash, swelling, or difficulty breathing.

References

Related Articles