What is Serotonin Syndrome and How Do You Know If You Have It?
Medically reviewed by Faith Coleman, University of New Mexico School of Medicine on August 23rd, 2026.
Serotonin syndrome is a potentially life-threatening condition caused by excessive serotonin activity in the brain. It typically occurs when you take multiple medications that increase serotonin levels, such as antidepressants, pain medications, or migraine drugs. Symptoms include high fever (often above 101.3°F), rapid heart rate, muscle rigidity, confusion, and profuse sweating. More severe cases involve seizures, irregular heartbeat, and loss of consciousness. The condition develops within hours to days of starting new medications or increasing doses. Mental status changes like agitation, hallucinations, and confusion are early warning signs. If you experience these symptoms seek emergency medical care immediately. If you are taking serotonin-enhancing drugs, serotonin syndrome is a possibility. Untreated, it can be fatal.
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