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What Antidepressant Has the Fewest Sexual Side Effects?
Choosing Depression Medication Wisely
March 31st, 2026
What Antidepressant Has the Fewest Sexual Side Effects?
Bupropion (Wellbutrin) has the fewest sexual side effects among antidepressants. Unlike SSRIs and SNRIs, bupropion works on dopamine and norepinephrine rather than serotonin, which helps preserve sexual function. Studies show that only 8-15% of patients taking bupropion experience sexual side effects, compared to 30-70% with SSRIs like sertraline or paroxetine. Mirtazapine (Remeron) also has relatively lower rates of sexual dysfunction, affecting about 15-20% of users. Some doctors prescribe bupropion alongside other antidepressants specifically to counteract sexual side effects. If you're experiencing sexual dysfunction with your current antidepressant, discuss switching options with your healthcare provider rather than stopping medication abruptly.
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