How Does Mounjaro Work
Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 20th, 2026.
Mounjaro works by mimicking two key hormones that regulate blood sugar and appetite. The medication contains tirzepatide, which activates both GLP-1 and GIP receptors in the body. These hormones slow gastric emptying, increase insulin production when blood sugar rises, and signal fullness to the brain. Clinical trials demonstrate that Mounjaro helps people lose 15-22% of their body weight over 72 weeks. The dual-hormone approach makes it more effective than single-hormone medications like Ozempic.
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