What is the Highest Dose of Zepbound
Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on February 19th, 2026.
The highest approved dose of Zepbound (tirzepatide) is 15 mg administered once weekly by subcutaneous injection. Patients typically start at 2.5 mg weekly for the first four weeks, then increase to 5 mg weekly. If additional weight loss is needed after at least four weeks on 5 mg, the dose can be escalated to 7.5 mg, then 10 mg, and finally to the maximum 15 mg dose. Each dose increase occurs at four-week intervals to allow your body to adjust and minimize side effects. Clinical trials showed that patients on the 15 mg dose achieved an average weight loss of 20.9% of their initial body weight over 72 weeks.
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