Where to Inject Zepbound
Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 20th, 2026.
Zepbound should be injected subcutaneously in the thigh, upper arm, or abdomen. The thigh is often preferred for its accessibility and larger injection area. Rotate injection sites within the same body region to prevent lipodystrophy and maintain proper absorption. Avoid areas with scars, bruises, or stretch marks. The abdomen provides good absorption but avoid the 2-inch area around the navel. The upper arm requires assistance from others but offers excellent absorption rates. Clean the injection site with alcohol before administration and allow it to dry completely. Never inject into muscle tissue or veins, as this can cause complications and affect medication effectiveness.
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