Does Wellbutrin Cause Weight Loss?
Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 21st, 2026.
Yes, Wellbutrin commonly causes weight loss as a side effect. Studies show that up to 28% of patients experience moderate weight reduction while taking this antidepressant. Unlike many other antidepressants that often cause weight gain, Wellbutrin (bupropion) works by blocking dopamine and norepinephrine reuptake, which can suppress appetite and increase energy expenditure. Most patients who experience weight loss see a reduction of 5-15 pounds over 6-12 months of treatment. The weight loss effect typically occurs gradually and may be more pronounced in the first few months of treatment.
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