Mental Health

Does Wellbutrin Affect Your Sex Drive?

Linda Girgis | MD

Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 21st, 2026.

Wellbutrin typically increases or maintains sex drive rather than decreasing it. Unlike many antidepressants that cause sexual side effects, bupropion (Wellbutrin) is often considered sexually neutral or even enhancing. Studies show that 70-80% of people taking SSRIs experience sexual dysfunction, while Wellbutrin users report significantly fewer sexual problems. In fact, doctors sometimes prescribe Wellbutrin specifically to counteract sexual side effects from other antidepressants. The medication works on dopamine and norepinephrine pathways rather than serotonin, which helps preserve sexual function. Some people may experience increased libido as a side effect.

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