Does Trazodone Cause Weight Gain?

Trazodone typically causes modest weight gain, with studies showing an average increase of 1-10 pounds over several months of treatment. This weight gain occurs in approximately 5-9% of patients taking the medication. The mechanism involves trazodone's effects on serotonin receptors and histamine pathways, which can increase appetite and slow metabolism. Weight changes are generally dose-dependent, meaning higher doses may lead to more significant weight gain. Most patients experience stabilization after the first few months of treatment. The benefits of improved sleep and reduced depression often outweigh the potential for minor weight gain, but monitoring your weight during treatment is recommended.