Mental Health

Does Sertraline Affect Your Period?

Andre Stone | MD

Medically reviewed by Andre Stone | MD, University of Pittsburgh School of Medicine on August 25th, 2026.

Yes, sertraline can affect your menstrual cycle and period. Sertraline and other SSRIs have been associated with changes in menstrual bleeding, but the cause and frequency are not well established. SSRIs can also increase bleeding tendency by affecting how platelets work. Menstrual changes may occur after starting sertraline, but their timing and duration can vary. Do not assume that a persistent or significant change is only an adjustment to the medication; ask your healthcare provider about other possible causes. Contact your healthcare provider if you develop persistent menstrual changes. Take a pregnancy test if pregnancy is possible and your period is late or missed. Seek urgent care for very heavy bleeding, fainting, severe dizziness, shortness of breath, or severe pain. Do not stop or change sertraline without medical guidance.

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