Does Ozempic Need to Be Refrigerated
Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 20th, 2026.
Yes, Ozempic must be refrigerated to maintain its effectiveness and safety. We recommend storing unopened Ozempic pens at 36-46°F (2-8°C) in your refrigerator, away from the freezer compartment. Once you start using a pen, you can keep it at room temperature (below 86°F/30°C) for up to 56 days, but refrigeration is still preferred. Never freeze Ozempic, as this destroys the medication's active ingredient, semaglutide. If accidentally frozen, discard the pen immediately. Always check the solution before each injection - it should be clear and colorless. If you're traveling or need personalized guidance on Ozempic storage and administration, I can help you understand the best practices for your specific situation.
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