Can You Take Xanax and Zoloft Together?

Yes, Xanax and Zoloft can be taken together under medical supervision. Many doctors prescribe this combination to treat anxiety and depression simultaneously. Xanax (alprazolam) can relieve anxiety quickly, while Zoloft (sertraline) may take several weeks to provide its full benefit, although the timing varies from person to person. Studies show this combination can be effective for patients with comorbid anxiety and depression. However, the combination may increase drowsiness, dizziness, and impaired coordination. Avoid alcohol and do not drive until you know how the medicines affect you. Alprazolam can also cause dependence and withdrawal, so take it only as prescribed and do not stop it suddenly. Your doctor will choose and adjust the doses based on your symptoms, side effects, and other medications.