Can You Take Ashwagandha with Lexapro?

Ashwagandha can potentially interact with Lexapro, so caution is advised. Both substances affect serotonin levels and neurotransmitter activity, which may lead to unpredictable interactions. Ashwagandha has been shown to reduce cortisol levels by up to 30% in clinical studies, potentially amplifying Lexapro's effects or causing excessive sedation. The herb may also affect GABA receptors, which could interfere with Lexapro's mechanism of action. Some users report increased drowsiness, mood changes, or altered anxiety levels when combining these substances. Always consult your healthcare provider before adding ashwagandha to your regimen while taking Lexapro, as they can assess your specific situation and monitor for potential interactions.