Get Zyclara Online
Zyclara (imiquimod 3.75%) is a prescription topical cream that helps clear actinic keratoses on the face and scalp. Get evaluated by a licensed physician online and receive a treatment plan without leaving home.
What Is Zyclara?
Zyclara (imiquimod 3.75%) is a prescription medication used to manage actinic keratosis on the face and scalp. It works by activating the local immune response through toll-like receptor 7 agonism, stimulating cytokine release that targets and clears abnormal keratinocytes. With the right dosing schedule and ongoing monitoring, most patients see meaningful clearance of actinic keratoses and reduced risk of progression.
- Targets actinic keratoses by activating your skin's own immune response
- Get personalized guidance from doctor-trained AI
- Explore treatment and prescription options
Is Online Zyclara Treatment Right for You?
Doctronic can evaluate you for Zyclara (imiquimod 3.75%) if you have clinically recognized actinic keratoses on the face or scalp, have no contraindications to topical imiquimod, and are not currently experiencing severe local skin reactions that require in-person assessment.
Because actinic keratosis involves chronic ultraviolet-induced skin damage, your physician will also review your skin cancer history, immune status, and any prior treatments for precancerous or cancerous skin lesions to ensure Zyclara is the right choice for you.
- Diagnosed with actinic keratosis on the face or scalp
- Get personalized guidance from AI and clinicians
- Explore treatment and prescription refill options
- Access care from home, often the same day
Medications We Prescribe for Actinic Keratosis
Zyclara
Imiquimod 3.75%
First-line topical immunomodulator for actinic keratosis on the face and scalp; applied once daily for two 2-week treatment cycles.
AvailableAldara
Imiquimod 5%
Higher-strength imiquimod cream also indicated for actinic keratosis; applied three times per week for 16 weeks.
AvailableAklief
Trifarotene
Topical retinoid that promotes normalization of keratinocyte differentiation; may be considered for patients with concurrent photodamage concerns.
AvailableCarac / Efudex alternative - Salicylic Acid
Salicylic Acid
Keratolytic agent that aids in softening and removing hyperkeratotic lesions; sometimes used as an adjunct to primary actinic keratosis therapy.
AvailableHow Actinic Keratosis Treatment Works at Doctronic
Chat With The #1 AI Doctor
Doctronic answers your health questions with personalized medical insights and helps our doctors create a better treatment plan for you.
Meet With a Licensed Doctor For Treatment
Book a $39 telehealth appointment (or copay) within 30 minutes. Our doctors create personalized treatment plans with prescriptions when needed.
Pick Up Your Prescription
Our doctors prescribe non-controlled medications in all 50 states and send prescriptions to your pharmacy for same-day pickup.
What a Doctronic consultation looks like
Free to start, no account needed. Here's how a real Actinic Keratosis consultation unfolds.
Describe your symptoms
Type what you're feeling — no forms, no dropdowns.
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Built by doctors to rule out serious conditions first.
Doctor-trained AIGet your assessment + next steps
Instant clinical assessment — then connect to a doctor if needed, no repeating yourself.
$39 doctor visit · All 50 statesPricing that won't make you sick
Chat for free, see an online doctor for $39/visit, or refill a prescription online for as low as $0
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Available in all 50 states + DC
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Insurance accepted
- 24/7 medical care Free
- Specialist referrals Free
- Lifelong health record Free
- Unlimited questions Free
- Prescription refills Starting as low as $0
- Video visit with real doctors $39/visit
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Frequently asked questions
Zyclara (imiquimod 3.75%) is a topical immune response modifier. It activates toll-like receptor 7 on immune cells in the skin, triggering the release of interferons and other cytokines that destroy abnormal keratinocytes associated with actinic keratoses.
Zyclara is typically applied once daily at bedtime to the entire affected area on the face or scalp. The standard regimen consists of two 2-week treatment cycles separated by a 2-week rest period, for a total of 8 weeks. Follow your prescriber's specific instructions.
Local skin reactions including redness, flaking, scabbing, swelling, and erosion are common and generally indicate the medication is working. Severe reactions such as open sores, significant swelling, or flu-like symptoms should be reported to your physician promptly.
Zyclara 3.75% is specifically indicated for actinic keratoses on the face and scalp. Use on other body areas has not been established for this formulation. Your physician can discuss alternative treatments if lesions are located elsewhere.
Yes. Sun exposure can worsen skin reactions during treatment and further damage treated skin. You should minimize UV exposure, use protective clothing, and apply broad-spectrum sunscreen to untreated skin throughout your course of therapy.
Caution is warranted in patients who are immunosuppressed. Imiquimod works by stimulating the immune system, and its safety and efficacy profile may differ in immunocompromised individuals. Your physician will carefully review your immune status before prescribing.
Doctronic uses an AI-guided evaluation to collect your symptoms, medical history, and relevant details. A licensed physician then reviews your information, makes a clinical determination, and if appropriate, creates a personalized treatment plan that may include a prescription.
Yes. Doctronic's evaluations are conducted by licensed physicians, are doctor-reviewed and audited for quality, and the platform is fully HIPAA-compliant. Your health information is kept private and secure at every step.
Top Conditions We Can Help With
People turn to Doctronic and our licensed medical team for support with all types of conditions.