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Fetzima (levomilnacipran) is FDA-approved for the treatment of major depressive disorder (MDD) in adults. It is not approved for use in pediatric patients.

Fetzima is a serotonin-norepinephrine reuptake inhibitor (SNRI). It blocks the reabsorption of both serotonin and norepinephrine in the brain, which helps improve mood, energy, and other depressive symptoms. Compared to other SNRIs, it has relatively greater potency for norepinephrine reuptake inhibition.

The typical starting dose is 20 mg once daily for two days, after which it is increased to 40 mg once daily. Depending on tolerability and response, a physician may adjust the dose up to a maximum of 120 mg once daily. Fetzima should be swallowed whole and can be taken with or without food.

Common side effects include nausea, constipation, increased heart rate, elevated blood pressure, excessive sweating, and urinary hesitation. Most side effects are dose-dependent. Tell your doctor about any side effects that are bothersome or do not go away.

Fetzima carries a boxed warning about increased risk of suicidal thoughts in children, adolescents, and young adults. It should not be taken with MAO inhibitors due to risk of serotonin syndrome. It can raise blood pressure and heart rate, so monitoring is important. Inform your physician of all medications and supplements you take before starting Fetzima.

Some patients notice improvements in energy or sleep within the first one to two weeks, but full antidepressant effects typically take four to eight weeks. It is important to continue taking Fetzima as prescribed even if you do not notice immediate improvement.

No. Stopping Fetzima abruptly can cause discontinuation symptoms such as dizziness, irritability, nausea, and sensory disturbances. Always work with your physician to taper the dose gradually when discontinuing.

Doctronic uses AI-powered evaluation to gather your symptoms and medical history, which is then reviewed by a licensed physician. If appropriate, the physician creates a personalized treatment plan that may include a prescription. The entire process is HIPAA-compliant and available to adults 18 and older in any U.S. state.