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Emend (aprepitant) is a prescription antiemetic that blocks neurokinin-1 (NK1) receptors in the brain. Substance P, a neurotransmitter involved in triggering nausea and vomiting, is blocked from binding to these receptors, helping to prevent both acute nausea (within 24 hours of chemotherapy) and delayed nausea (occurring 2 to 5 days after chemotherapy).

Emend is typically taken as a 3-day oral regimen. A higher dose (usually 125 mg) is taken about one hour before chemotherapy on day one, followed by a lower dose (usually 80 mg) on the morning of days two and three. It is almost always used in combination with a 5-HT3 antagonist such as ondansetron and a corticosteroid such as dexamethasone.

Emend is approved for prevention of nausea and vomiting associated with highly emetogenic chemotherapy regimens (such as those containing cisplatin) and moderately emetogenic chemotherapy regimens. It is not intended for routine use with low-emetogenic or minimally emetogenic chemotherapy.

Yes. Aprepitant is a moderate inhibitor and inducer of the CYP3A4 enzyme, which means it can increase or decrease the blood levels of many other medications. Notably, it is contraindicated with pimozide and cisapride. It can also reduce the effectiveness of hormonal contraceptives, so an alternative or backup method of contraception is recommended during treatment and for 28 days after the last dose. Always share a complete list of your medications with your physician.

Emend is specifically FDA-approved for chemotherapy-induced nausea and vomiting and for prevention of postoperative nausea and vomiting. It is not generally indicated for nausea from other causes such as motion sickness or viral illness. Your physician will evaluate whether Emend is appropriate for your specific situation.

Common side effects include fatigue, hiccups, constipation, diarrhea, loss of appetite, and headache. Some patients also experience elevated liver enzyme levels. Serious hypersensitivity reactions, including anaphylaxis, have been reported rarely. Contact your care team promptly if you experience a rash, difficulty breathing, or swelling after taking Emend.

Doctronic uses an AI-guided evaluation to gather a thorough picture of your symptoms, medical history, and current medications. That information is then reviewed by a licensed physician, who determines whether a treatment plan including a prescription is appropriate for you. The entire process is streamlined so you can get clinically sound care without an in-person visit.

Yes. Doctronic connects patients with fully licensed physicians who review every case individually. All consultations are HIPAA-compliant, and prescribing decisions are doctor-reviewed and audited for quality. Doctronic is available to adults 18 and older in any U.S. state.