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Dolobid (diflunisal) is prescribed for mild to moderate pain and for managing the signs and symptoms of osteoarthritis and rheumatoid arthritis, including joint pain, swelling, and stiffness.

Although diflunisal is structurally derived from salicylic acid like aspirin, it does not significantly convert to salicylate in the body and has a longer duration of action, typically allowing twice-daily dosing rather than more frequent doses.

For arthritis, Dolobid is typically taken as 250 mg to 500 mg twice daily. For acute pain, an initial dose of 1000 mg is often followed by 500 mg every 8 to 12 hours. Your physician will determine the appropriate dose based on your condition and response.

Common side effects include stomach upset, nausea, and headache. More serious but less common risks include gastrointestinal bleeding, kidney function changes, elevated blood pressure, and cardiovascular events. Contact your provider promptly if you notice unusual symptoms.

Dolobid can interact with anticoagulants such as warfarin, other NSAIDs, and certain blood pressure medications. Always tell your provider about every medication and supplement you take before starting diflunisal.

Dolobid is generally not appropriate for people with a history of peptic ulcer disease, severe kidney or liver impairment, heart failure, or known hypersensitivity to diflunisal or other NSAIDs. It is also contraindicated for use around the time of coronary artery bypass graft surgery.

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