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Colchicine is prescribed to treat and prevent acute gout flares. It works by interfering with the inflammatory response triggered by uric acid crystals deposited in joints, reducing pain, swelling, and redness. It is also approved for familial Mediterranean fever.

For an acute flare, the standard adult dose is 1.2 mg at the first sign of a flare, followed by 0.6 mg one hour later. For prevention, 0.6 mg once or twice daily is typical. Your physician will confirm the appropriate dose based on your kidney function and other medications.

Yes. Long-term low-dose colchicine is commonly prescribed to prevent recurrent gout flares, especially when starting urate-lowering therapy. Your doctor will periodically reassess your dose and monitor for any side effects or drug interactions.

The most frequently reported side effects are gastrointestinal, including diarrhea, nausea, vomiting, and abdominal cramping. These are more common at higher doses. Rarely, prolonged use at higher doses can cause muscle weakness or blood count changes, particularly in patients with kidney or liver impairment.

Yes. Colchicine has important interactions with CYP3A4 and P-glycoprotein inhibitors such as clarithromycin, cyclosporine, and certain antifungals. These combinations can raise colchicine blood levels and increase the risk of toxicity. Always provide your full medication list to your physician.

No. Colchicine reduces inflammation during gout attacks and prevents flares, but it does not lower serum uric acid. Urate-lowering medications such as allopurinol or febuxostat are prescribed separately to address elevated uric acid levels over the long term.

Recent kidney and liver function tests are helpful for safe prescribing, as colchicine doses may need to be reduced in patients with renal or hepatic impairment. Your Doctronic physician will let you know if updated labs are needed based on your history.

Doctronic uses an AI-guided evaluation to gather your symptoms and medical history, which is then reviewed by a licensed physician. The physician creates a personalized treatment plan, which may include a prescription if medically appropriate. The entire process is HIPAA-compliant and available to adults 18 and older in any U.S. state.