How Do NSAIDs Affect Your Digestive System?
Published: Nov 10, 2023
NSAIDs are commonly used for pain relief, but they can cause serious digestive system issues.
Contents
Stomach Problems
NSAIDs can lead to stomach problems such as dyspepsia, ulcers, and bleeding. These issues arise because NSAIDs reduce the production of protective stomach lining substances, making the stomach more vulnerable to damage by stomach acid.
Risk Factors for Gastrointestinal Effects
Certain factors increase the risk of gastrointestinal issues, including a history of ulcers, being over 60, taking high doses of NSAIDs, and using other medications like glucocorticoids and antiplatelet agents. Managing these risk factors is crucial to prevent serious complications.

Preventive Measures
To reduce the risk of gastrointestinal issues, it's important to use the lowest effective NSAID dose and consider protective medications like proton pump inhibitors. Consulting with a healthcare provider can help tailor a safe and effective treatment plan.
Frequently Asked Questions
Yes, they can lead to ulcers and bleeding.
Older adults and those with a history of ulcers.
Use the lowest dose and consult a doctor.
Yes, drugs like glucocorticoids increase risk.
Wrapping Up
Being aware of NSAID's effects on the digestive system can help you avoid potential problems.
References
- Rostom A, Goldkind L, Laine L. Nonsteroidal anti-inflammatory drugs and hepatic toxicity: a systematic review of randomized controlled trials in arthritis patients. Clin Gastroenterol Hepatol 2005; 3:489.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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