Pregnancy & Medication Safety

What Nasal Spray is Safe During Pregnancy?

Linda Girgis | MD

Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 22nd, 2026.

Saline nasal sprays are considered the safest option during pregnancy for nasal congestion relief. These contain only salt water and pose no risk to developing babies. The American College of Obstetricians and Gynecologists recommends saline sprays as a first-line treatment for pregnancy rhinitis, which affects up to 30% of pregnant women. Brands like Ocean, Simply Saline, and Ayr are widely available over-the-counter options. Avoid decongestant sprays containing oxymetazoline or phenylephrine during the first trimester, as safety data is limited. Always consult your healthcare provider before using any nasal medications during pregnancy to ensure they're appropriate for your specific situation.

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