Pregnancy & Medication Safety

Can You Take Prilosec While Pregnant?

Linda Girgis | MD

Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 20th, 2026.

Prilosec (omeprazole) is generally considered safe during pregnancy when medically necessary. The FDA classifies omeprazole as a Category C medication, meaning animal studies have shown potential risks but human studies are limited. Multiple studies involving over 1,000 pregnant women have found no increased risk of major birth defects. However, heartburn during pregnancy can often be managed with safer alternatives like calcium carbonate antacids or dietary modifications. Your doctor will weigh the benefits against potential risks based on your specific symptoms and medical history. Always consult your healthcare provider before starting or continuing Prilosec during pregnancy to ensure it's the right choice for your situation.

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