Can You Take Zofran for Morning Sickness?

Yes, Zofran (ondansetron) can be prescribed for morning sickness when other treatments haven't worked. Healthcare providers typically reserve Zofran for moderate to severe nausea and vomiting of pregnancy (NVP) affecting 70-80% of pregnant women. The FDA hasn't specifically approved Zofran for pregnancy, but it's commonly used off-label when first-line treatments like vitamin B6, doxylamine, or dietary changes prove insufficient. Studies show Zofran effectively reduces nausea in 60-70% of pregnant patients. However, some research suggests potential risks including small increases in birth defects, particularly cleft palate. Your doctor will weigh these benefits and risks based on your specific situation and severity of symptoms.