What is the Highest Dose of Mounjaro

The highest FDA-approved dose of Mounjaro (tirzepatide) is 15 mg once weekly. The medication follows a structured escalation schedule starting at 2.5 mg, increasing every 4 weeks through 5 mg, 7.5 mg, 10 mg, 12.5 mg, and finally 15 mg. This gradual increase helps minimize gastrointestinal side effects while maximizing therapeutic benefits. Clinical trials showed the 15 mg dose achieved average weight loss of 22.5% over 72 weeks. Your healthcare provider determines the optimal dose based on your individual response and tolerance to the medication.