Pregnancy & Medication Safety

What Happens If You Take Pepto-Bismol in Early Pregnancy?

Andre Stone | MD

Medically reviewed by Andre Stone | MD, University of Pittsburgh School of Medicine on August 25th, 2026.

Taking Pepto-Bismol during early pregnancy is not recommended due to salicylate content. The active ingredient bismuth subsalicylate contains salicylates, which are chemically similar to aspirin and may increase bleeding risk. Studies suggest salicylate exposure in the first trimester could potentially affect fetal development, though research remains limited. The FDA classifies Pepto-Bismol as Category C for pregnancy, meaning risk cannot be ruled out. Most healthcare providers advise avoiding it entirely during pregnancy, especially in the first trimester when organ development occurs. Safer alternatives for digestive issues include dietary modifications, ginger, or consulting your doctor about pregnancy-safe antacids.

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